Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

252010 Debromohymenialdisine, Stylotella aurantium

Debromohymenialdisine, Stylotella aurantium MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DBH

252010
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
OverviewAn alkaloid isolated from a shallow-water marine sponge that acts as a highly selective inhibitor of G2 phase DNA damage checkpoint (IC50 = 8 µM). Exhibits moderate cytotoxicity (IC50 = 25 µM) toward MCF-7 cells. Acts by blocking the activities of checkpoint kinases Chk1 (IC50 = 3 µM) and Chk2 (IC50 = 3.5 µM). Inhibition is competitive with respect to ATP and does not affect the activities of other kinases.
Catalogue Number252010
Brand Family Calbiochem®
SynonymsDBH
References
ReferencesCurman, D., et al. 2001. J. Biol. Chem. 276, 17914.
Product Information
CAS number125118-55-0
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₁H₁₁N₅O₂
Chemical formulaC₁₁H₁₁N₅O₂
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetG2 phase DNA damage checkpoint
Primary Target IC<sub>50</sub>8 µM
Secondary targetChk1 (IC₅₀ = 3 µM) and Chk2 (IC₅₀ = 3.5 µM), cytotoxicity (IC₅₀ = 25 µM) toward MCF-7 cells
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
252010 0

Documentation

Debromohymenialdisine, Stylotella aurantium Certificates of Analysis

TitleLot Number
252010

References

Hivatkozások áttekintése
Curman, D., et al. 2001. J. Biol. Chem. 276, 17914.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-December-2008 RFH
SynonymsDBH
DescriptionAn alkaloid isolated from a shallow-water marine sponge that acts as a highly selective blocker of the G2 phase of the cell cycle (DNA damage checkpoint) (IC50 = 8 µM). Acts by blocking the activities of the check point kinases, Chk1 (IC50 = 3 µM) and Chk2 (IC50 = 3.5 µM), thus interfering with inhibitory phosphorylation of Cdc2 kinase, resulting in its activation. The inhibition is shown to be competitive with respect to ATP. Exhibits only moderate cytotoxicity in the absence of DNA-damaging agents (IC50 = 25 µM). Does not inhibit other DNA damage checkpoint kinases such as ATM, ATR, and DNA-PK.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number125118-55-0
Chemical formulaC₁₁H₁₁N₅O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCurman, D., et al. 2001. J. Biol. Chem. 276, 17914.