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317200 DMBI

DMBI MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-3-[4-(Dimethylamino)benzylidenyl]indolin-2-one, SU 4312, PDGFR Tyrosine Kinase Inhibitor XIV

Primary Target: B-PDGFR
317200
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
5812-07-7C₁₇H₁₆N₂O
Description
Overview

This product has been discontinued.





A cell-permeable, reversible, ATP-competitive, and potent inhibitor of the tyrosine kinase activities of the PDGF β-receptor (β-PDGFR; IC50 = 4 µM in PAC-1 cells) and FGFR1 (IC50 = 5 µM for inhibition of tyrosine phosphorylation of p90). Does not inhibit EGFR or c-Src tyrosine kinases, even at concentrations greater than 100 µM.
Catalogue Number317200
Brand Family Calbiochem®
Synonyms(Z)-3-[4-(Dimethylamino)benzylidenyl]indolin-2-one, SU 4312, PDGFR Tyrosine Kinase Inhibitor XIV
References
ReferencesKendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
Product Information
CAS number5812-07-7
ATP CompetitiveY
FormOrange-red solid
Hill FormulaC₁₇H₁₆N₂O
Chemical formulaC₁₇H₁₆N₂O
ReversibleY
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetB-PDGFR
Primary Target IC<sub>50</sub>4 µM against β-PDGFR in PAC-1 cells
Purity≥95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
317200 0

Documentation

DMBI MSDS

Title

Safety Data Sheet (SDS) 

DMBI Certificates of Analysis

TitleLot Number
317200

References

Hivatkozások áttekintése
Kendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms(Z)-3-[4-(Dimethylamino)benzylidenyl]indolin-2-one, SU 4312, PDGFR Tyrosine Kinase Inhibitor XIV
DescriptionA cell-permeable, reversible, ATP-competitive, and potent inhibitor of the tyrosine kinase activity of the PDGF β-receptor (β-PDGFR; IC50 = 4 µM in PAC-1 cells). Also inhibits FGFR1 tyrosine kinase activity (IC50 = 5 µM for inhibition of tyrosine phosphorylation of p90). Does not inhibit EGFR or c-Src tyrosine kinases, even at concentrations greater than 100 µM.
FormOrange-red solid
Intert gas (Yes/No) Packaged under inert gas
CAS number5812-07-7
Chemical formulaC₁₇H₁₆N₂O
Structure formulaStructure formula
Purity≥95% by HPLC (sum of two isomers)
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKendall, R.L., et al. 1999. J. Biol. Chem. 274, 6453.
Zaman, G.J., et al. 1999. Biochem. Pharmacol. 57, 57.
Sun, L., et al. 1998. J. Med. Chem. 41, 2588.