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234200 Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization as well as cellular microtubule assembly

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4

234200
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
117048-59-6C₁₈H₂₀O₅

Products

KatalógusszámCsomagolás Menny./csomag
234200-10MG 10 mg
Description
OverviewA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
Catalogue Number234200
Brand Family Calbiochem®
SynonymsCombretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4
References
ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
Product Information
CAS number117048-59-6
FormOff-white solid
Hill FormulaC₁₈H₂₀O₅
Chemical formulaC₁₈H₂₀O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
234200-10MG 04055977200126

Documentation

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem Certificates of Analysis

TitleLot Number
234200

References

Hivatkozások áttekintése
Tron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2010 RFH
SynonymsCombretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII, NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4
DescriptionA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat. No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number117048-59-6
Chemical formulaC₁₈H₂₀O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.