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234109 Colcemid - CAS 477-30-5 - Calbiochem

Cell synchronization agent.

Colcemid - CAS 477-30-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Demecolcine

Primary Target: Depolymerizes microtubules and limits microtubule formation.
234109
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
477-30-5C₂₁H₂₅NO₅

Products

KatalógusszámCsomagolás Menny./csomag
234109-5MG Alumíniumdob 5 mg
Description
OverviewCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
Catalogue Number234109
Brand Family Calbiochem®
SynonymsDemecolcine
References
ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.
Product Information
CAS number477-30-5
ATP CompetitiveN
FormCrystalline powder
Hill FormulaC₂₁H₂₅NO₅
Chemical formulaC₂₁H₂₅NO₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDepolymerizes microtubules and limits microtubule formation.
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGH0800000
Safety Information
R PhraseR: 25-63

Toxic if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
234109-5MG 04055977199956

Documentation

Colcemid - CAS 477-30-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Colcemid - CAS 477-30-5 - Calbiochem Certificates of Analysis

TitleLot Number
234109

References

Hivatkozások áttekintése
Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsDemecolcine
DescriptionCell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.
FormCrystalline powder
CAS number477-30-5
RTECSGH0800000
Chemical formulaC₂₁H₂₅NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol and chloroform (10 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 2887
ReferencesUrbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res. 198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res. 31, 494.