218699 Casein Kinase II Inhibitor II, DMAT
Recommended Products
Áttekintés
| Replacement Information |
|---|
| Description | |
|---|---|
| Overview | This product has been discontinued. We are offering Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information. A cell-permeable brominated benzimidazolo compound that acts as a potent, high affinity and ATP-competitive inhibitor of CK2 (IC50 = 140 nM for rat liver CK2; Ki = 40 nM). Displays ~1300 fold greater selectivity over CK1 (IC50 > 200 µM) and is superior to CK2 inhibitor, TBB (Cat. No. 218697). Inhibits dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1a) with comparable efficacy and minimally affects the activities of 30 other protein kinases tested. Shown to induce apoptosis in Jurkat T cells at 2.5 µM. A 10 mM (5 mg/1.05 ml) solution of Casein Kinase II Inhibitor, DMAT (Cat. No. 218706), in DMSO is also avialable. |
| Catalogue Number | 218699 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole, CK2 Inhibitor II, DMAT |
| References | |
|---|---|
| References | Pagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040. |
| Product Information | |
|---|---|
| CAS number | 749234-11-5 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₉H₇Br₄N₃ |
| Chemical formula | C₉H₇Br₄N₃ |
| Structure formula Image | |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | CK2 |
| Primary Target IC<sub>50</sub> | 140 nM |
| Secondary target | CK2 Ki = 40 nM, CK1 (IC₅₀ > 200 µM) |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Katalógusszám | GTIN |
| 218699 | 0 |
Documentation
Casein Kinase II Inhibitor II, DMAT MSDS
| Title |
|---|
Casein Kinase II Inhibitor II, DMAT Certificates of Analysis
| Title | Lot Number |
|---|---|
| 218699 |
References
| Hivatkozások áttekintése |
|---|
| Pagano, M.A., et al 2004. J. Med. Chem. 47 6239. Pagano, M.A., et al. 2004. Biochem. Biophys. Res. Commun. 321, 1040. |
| Data Sheet | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
|