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217504 Cardiotoxin, Naja nigricollis

A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro.

Cardiotoxin, Naja nigricollis MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.



We are offering Cardiotoxin, Naja pallida (Cat. No. 217503) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by the sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
Catalogue Number217504
Brand Family Calbiochem®
References
ReferencesJang, J.Y., et al. 1997. Biochemistry 36, 4635.
Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.
Product Information
ATP CompetitiveN
DeclarationNot available for sale outside of the United States.
FormLyophilized solid
Hill FormulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
Chemical formulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
ReversibleN
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>1.8 µM against protein kinase C
Purity≥95% by IEF
Physicochemical Information
Cell permeableN
Contaminantsphospholipase A₂ activity: <2%
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFH7482450
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
217504 0

Documentation

Cardiotoxin, Naja nigricollis Certificates of Analysis

TitleLot Number
217504

References

Hivatkozások áttekintése
Jang, J.Y., et al. 1997. Biochemistry 36, 4635.
Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2010 RFH
DescriptionA cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
FormLyophilized solid
RTECSFH7482450
Chemical formulaC₂₉₈H₄₉₃N₈₁O₇₇S₁₂
Purity≥95% by IEF
Contaminantsphospholipase A₂ activity: <2%
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 1835
ReferencesJang, J.Y., et al. 1997. Biochemistry 36, 4635.
Huang, J.L., and Trumble, W.R. 1991. Toxicon 29, 31.
Raynor, R.L., et al. 1991. J. Biol. Chem. 266, 2753.
Grognet, J.M., et al. 1986. Mol. Immunol. 23, 132.