504041 Sigma-AldrichCaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem
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Primary Target:
TMEM16A-CaCC
CaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV
Recommended Products
Áttekintés
| Replacement Information |
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Kulcsspecifikációk táblázata
| CAS # | Empirical Formula |
|---|---|
| 3562-84-3 | C₁₇H₁₂Br₂O₃ |
Products
| Katalógusszám | Csomagolás | Menny./csomag | |
|---|---|---|---|
| 5.04041.0001 | Üvegpalack | 100 mg |
| Description | |
|---|---|
| Overview | A cell-permeable uricosuric agent that, in addition to its known efficacy in gout treatment, acts as a reversible CaCC blocker and is reported to be more potent than NFA (Cat. No. 481987) and NPPB (Cat. No. 484100) in suppressing 500 nM Ionomycin- (Cat. Nos. 407950, 407952, and 407953) induced I- influx in TMEM16A-expressing HEK293 cells (IC50 = 9.97, 140, and 150 µM, respectively) as well as in blocking voltage-gated Cl- current in TMEM16B-expressing HEK293 cells, while exhibiting much reduced potency against ENaC (α, β, and γ) or CFTR. Shown to significantly reduce mucin secretion from NHBE (normal human bronchial epithelial) and suppress human ASM (airway smooth muscle) contraction upon muscarinic receptor stimulation. |
| Catalogue Number | 504041 |
| Brand Family | Calbiochem® |
| Synonyms | (3,5-dibromo-4-hydroxyphenyl)(2-ethylbenzofuran-3-yl)methanone, ANO Blocker IV, Anoctamin Blocker IV, BBR, CaCC Blocker IV, Calcium-Activated Chloride Channel Blocker IV, TMEM16 Blocker IV |
| Product Information | |
|---|---|
| CAS number | 3562-84-3 |
| Form | White powder |
| Hill Formula | C₁₇H₁₂Br₂O₃ |
| Chemical formula | C₁₇H₁₂Br₂O₃ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
|---|---|
| Primary Target | TMEM16A-CaCC |
| Purity | ≥97% by HPLC |
| Physicochemical Information |
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| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 25 Toxic if swallowed. |
| S Phrase | S: 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| Product Usage Statements |
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| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
|---|---|
| Katalógusszám | GTIN |
| 5.04041.0001 | 04055977264234 |
Documentation
CaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem MSDS
| Title |
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CaCC Blocker IV, Benzbromarone - CAS 3562-84-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 504041 |
References
| Hivatkozások áttekintése |
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| Kobayashi, K., et al. 2012. Drug Metab. Pharmacokinet. In press. Zhang, C.H., et al. 2013. Am. J. Respir. Crit. Care Med. 187, 374. Huang, F., et al. 2012. Proc. Natl. Acad. Sci. USA. 109, 16354. Fujimori, S., et al. 2011. Nucleosides Nucleotides Nucleic Acids 30, 1035. Perez-Ruiz, F., et al. 1998. Ann. Rheum. Dis. 57, 545. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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