203882 Sigma-AldrichCR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
A cell-permeable (R)-DRF053 analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor.
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Synonyms: 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8
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Áttekintés
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Kulcsspecifikációk táblázata
| CAS # | Empirical Formula |
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| 1084893-56-0 | C₂₄H₂₉N₇O |
| Description | |
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| Overview | A cell-permeable (R)-DRF053 (Cat. No. 219494) analog that acts as an ATP-binding pocket-targeting CDK/CK1 dual-specific inhibitor (IC50 = 0.15, 0.080, 0.060, 0.12, 0.11, and 0.61 µM against CDK1/B, CDK2/A, CDK2/E, CDK5/p25, CDK9/T, and CK1δ/ε, respectively). Although (S)-CR8 displays in general similar kinase inhibitory profile as its (R)-enantiomer (Cat. No. 203881), it does exhibit more enhanced and reduced activity against, respectively, Dyrk1A (IC50 = 0.9 µM) and GSK-3α/β (IC50 ≥ 30 µM). Both (R)- and (S)-CR8 are much more effective than (R)-Roscovitine (Cat. Nos. 550360 and 550364) in apoptosis induction in cell cultures. |
| Catalogue Number | 203882 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine, (S)-CR8 |
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| References | Bettayeb, K., et al. 2008. Oncogene 27, 5797. |
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| CAS number | 1084893-56-0 |
| Form | Off-white solid |
| Hill Formula | C₂₄H₂₉N₇O |
| Chemical formula | C₂₄H₂₉N₇O |
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| Quality Level | MQ100 |
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| Purity | ≥97% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Global Trade Item Number | |
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| Katalógusszám | GTIN |
| 203882 | 0 |
Documentation
CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem MSDS
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CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 203882 |
References
| Hivatkozások áttekintése |
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| Bettayeb, K., et al. 2008. Oncogene 27, 5797. |