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500503 CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem

CDC42 Inhibitor III, ZCL278 - CAS 587841-73-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)acetamide, CDC42 GTPase Inhibitor III

Primary Target: CDC42
500503
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
587841-73-4C₂₁H₁₉BrClN₅O₄S₂

Products

KatalógusszámCsomagolás Menny./csomag
5.00503.0001 Üvegpalack 25 mg
Hozzáadás a Kedvencekhez
Description
OverviewA cell-permeable, non-cytotoxic, aqueous soluble (181 µM in PBS, pH 7.4) pyrimidinylthiourea that targets Cdc42 GEF ITSN/intersectin and adjacent GTP/GDP binding site and effectively inhibits EGF-stimulated Cdc42 activity (1 h pretreatment; 50 µM) and Cdc42-dependent microspike/filopodia formation in serum-starved Swiss 3T3 fibroblast cultures without affecting RhoA- or Rac1-dependent functions. Short-term ZCL278 exposure in primary murine neonatal cortical neurons is shown to dramatically abolish neurite branching (50 µM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number500503
Brand Family Calbiochem®
Synonyms4-(3-(2-(4-Bromo-2-chloro-phenoxy)-acetyl)-thioureido)-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide, 2-(4-Bromo-2-chlorophenoxy)-N-((4-((4,6-dimethyl-2-pyrimidinyl)sulfamoyl)phenyl)carbamothioyl)acetamide, CDC42 GTPase Inhibitor III
References
ReferencesFriesland, A., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 1261.
Product Information
CAS number587841-73-4
FormLight beige solid
Hill FormulaC₂₁H₁₉BrClN₅O₄S₂
Chemical formulaC₂₁H₁₉BrClN₅O₄S₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCDC42
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
5.00503.0001 04055977245677