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420358 CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem

420358
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
4727-31-5C₂₀H₁₅NO₃

Products

KatalógusszámCsomagolás Menny./csomag
420358-25MG Üvegpalack 25 mg
Description
OverviewA cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
Catalogue Number420358
Brand Family Calbiochem®
Synonyms2-(Biphenyl-4-ylcarbamoyl)benzoic acid
References
ReferencesJohnson, K., et al. 2012. Science 336, 717.
Product Information
CAS number4727-31-5
FormWhite solid
Hill FormulaC₂₀H₁₅NO₃
Chemical formulaC₂₀H₁₅NO₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
420358-25MG 04055977187540

Documentation

CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

CBFβ Activator, Kartogenin - CAS 4727-31-5 - Calbiochem Certificates of Analysis

TitleLot Number
420358

References

Hivatkozások áttekintése
Johnson, K., et al. 2012. Science 336, 717.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms2-(Biphenyl-4-ylcarbamoyl)benzoic acid
DescriptionA cell-permeable biphenylcarbamoylbenzoate compound that potently induces the differentiation of human mesenchymal stem cells (hMSCs) into chondrocytes (EC50 = 100 nM). Reversibly binds to the FC-1 fragment of filamin A and disrupts its association with CBFβ leading to nuclear localization of CBFβ and binding to runt-related transcription factor (RUNX) to regulate chondrogenesis. Also reported to inhibit cytokine-induced release of nitric oxide (NO) and glycosaminoglycan (GAG). Exhibits chondroprotective properties and promotes cartilage repair in murine osteoarthritis models. Shown to up-regulate the levels of TIMP1, collagen, and aggrecan thereby blocking further matrix breakdown without affecting the activities of MMP-3, MMP-13, and aggrecanase in primary chondrocytes or hMSCs.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number4727-31-5
Chemical formulaC₂₀H₁₅NO₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJohnson, K., et al. 2012. Science 336, 717.