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205531 CA-074 Me - Calbiochem

CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.

CA-074 Me - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester

Primary Target: cathepsin B
205531
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₁₉H₃₁N₃O₆

Products

KatalógusszámCsomagolás Menny./csomag
205531-1MG Muanyagampulla 1 mg
Description
OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Catalogue Number205531
Brand Family Calbiochem®
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
References
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₁N₃O₆
Chemical formulaC₁₉H₃₁N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
205531-1MG 07790788048433

Documentation

CA-074 Me - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

CA-074 Me - Calbiochem Certificates of Analysis

TitleLot Number
205531

References

Hivatkozások áttekintése
Sever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

Citations

Titulus
IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
FormWhite solid
Chemical formulaC₁₉H₃₁N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.