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SCT092 BioTracker PyrPeg Amyloid-b Live Cell Dye

Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer's disease studies.

SCT092
1 mg  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
Catalogue NumberSCT092
DescriptionBioTracker PyrPeg Amyloid-b Live Cell Dye
OverviewAlzheimer’s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging.

BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).

Reference:
1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.
Alternate Names
  • Live Cell Imaging Probe
References
Product Information
Detection methodFluorescence
PresentationLyophilized. Orange solid.
Applications
ApplicationTwo-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer's disease studies.
Biological Information
Molecular Weight459.49
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
SCT092 04065265944489

Documentation