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SCT246 BioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe

BioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.

SCT246
1 mg  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
Catalogue NumberSCT246
DescriptionBioTracker BioCyTASQ G-Quadruplex (G4) Cell Probe
Alternate Names
  • G4 probe
  • G quadruplex probe
  • Live Cell Imaging Probe
  • G4 ligand
  • G4 tetrad probe
Background InformationDNA/RNA G-quadruplexes (G4s) are four-stranded nucleic acid structures that fold from numerous guanine (G)-rich sequences found in the genome and transcriptome. Their abundance and localization in critical regulatory regions make them key players in genetic diseases (cancer, neuropathology), but not only (e.g., viral infection). For this reason G4s have garnered intense interest as potential targets in different therapeutic areas.

The BioTracker™ BioCyTASQ G-quadruplex G4 cell probe is optimized for detection (1) and/or the isolation of G4s (2,3). BioCyTASQ utilizes the template-assembled synthetic G-quartets (TASQ) (4) concept as a biomimetic ligand for G-quadruplexes, a design which results in high specificity for folded G4.

References
1. ACS Chem Biol. 2021, 16: 905–914
2. Nature Protoc. 2022, 17: 870–889
3. STAR Protoc. 2024, 5: 103480
4. Acc. Chem. Res. 2023, 56: 350–362
5. iScience 2023, 26:106846
References
Product Information
Detection methodFluorescence
FormatLyophilized solid
PresentationLyophilized. White solid.
Quality LevelMQ100
Applications
ApplicationBioCyTASQ detects ribosomal RNA associated with perinuclear rough ER regions. BioCyTASQ is suitable for G4 capture pull-down assays as well as cellular imaging.2 BioCyTASQ G4 probe is not recommended for live-cell imaging applications. The biotinylated BioTracker BioCyTASQ G-quadruplex G4 cell probe makes is a powerful tool for biochemical and cellular analysis of G4 by fluorescent detection when used with a fluorescent streptavidin.
Key Applications
  • RNA Detection
  • DNA-binding Proteins
  • Nucleic Acid Purification and Concentration
Application NotesFluorescent detection of nucleic acid G4 quadruplexes in cells and tissues
Biological Information
Molecular Weight968 g/mol
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssurancePurity > 98% confirmed by HPLC, HNMR, LC-MS and elemental analysis.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker™ BioCyTASQ G-quadruplex G4 cell probe at -20°C, desiccated and protected from light
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
SCT246 04065268798782