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201125 Binucleine 2 - CAS 220088-42-6 - Calbiochem

Binucleine 2 - CAS 220088-42-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII

201125
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
220088-42-6C₁₃H₁₁ClFN₅
Description
Overview

This product has been discontinued.



A cell-permeable pyrazolo compound that inhibits cytokinesis function of the Aurora B kinase pathway. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, while inactive in mammalian systems. Does neither function as a general kinase inhibitor nor inhibit Cdk-dependent entry into mitosis.
Catalogue Number201125
Brand Family Calbiochem®
SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
References
ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
Product Information
CAS number220088-42-6
FormBrown solid
Hill FormulaC₁₃H₁₁ClFN₅
Chemical formulaC₁₃H₁₁ClFN₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
201125 0

Documentation

Binucleine 2 - CAS 220088-42-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Binucleine 2 - CAS 220088-42-6 - Calbiochem Certificates of Analysis

TitleLot Number
201125

References

Hivatkozások áttekintése
Eggert, U.S., et al. 2004. PLoS Biol. 2, 2135.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-February-2008 JSW
SynonymsNʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII
DescriptionA cell-permeable pyrazolo compound that inhibits the cytokinesis function of the Aurora B kinase pathway. Shown to inhibit Aurora β-dependent phosphorylation, but not a general kinase inhibitor. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, but is inactive in mammalian systems. Inhibit Cdk-dependent entry into mitosis.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number220088-42-6
Chemical formulaC₁₃H₁₁ClFN₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesEggert, U.S., et al. 2004. PLoS Biol. 2, 2135.