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200980 Bikinin - CAS 188011-69-0 - Calbiochem

A cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor.

Bikinin - CAS 188011-69-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Arabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor, 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid

200980
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
188011-69-0C₉H₉BrN₂O₃
Description
OverviewA cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor against 7 of the 10 Arabidopsis thaliana GSK3's, BIN2 & ASKα/ γ/ε/ζ/ι/θ, but not ASKβ/δ or three other Arabidopsis Ser/Thr kinases, AtMPK4, AtMPK6, and AtAURORA1. The inhibitory activity is plant species-selective, as Bikinin exhibits much reduced activity against human Gsk-3β, Aurora B, Aurora C (45.6%, 69.4%, and 42.8% inhibition, respectively, with 10 µM Bikinin), and little or no activity against 74 other human kinases, nor does it affect GSK-3β-mediated dorsoventral axis formation during Xenopus embryo development. Bikinin at 30 µM is shown to bypass brassinolide (BL) and BRI1 and effectively activate brassinosteroid (BR) signaling responses in Arabidopsis thaliana seedings, including decreased BES1 phosphorylation, increased hypocotyl length, long and bending petioles, blade-shaped, pale-green leaves, as well as reduced lateral root density.
Catalogue Number200980
Brand Family Calbiochem®
SynonymsArabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor, 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid
References
ReferencesRybel, B.D., et al. 2009. Chem. Biol. 16, 594.
Product Information
CAS number188011-69-0
FormWhite solid
Hill FormulaC₉H₉BrN₂O₃
Chemical formulaC₉H₉BrN₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
200980 0

Documentation

Bikinin - CAS 188011-69-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Bikinin - CAS 188011-69-0 - Calbiochem Certificates of Analysis

TitleLot Number
200980

References

Hivatkozások áttekintése
Rybel, B.D., et al. 2009. Chem. Biol. 16, 594.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
SynonymsArabidopsis GSK-3 Inhibitor, Arabidopsis SHAGGY-related Kinase Inhibitor, GSK-3-like Kinase BIN2 Inhibitor, 4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid
DescriptionA cell-permeable nonsteroidal pyridinylamido compound that acts as an ATP-competitive inhibitor against 7 of the 10 Arabidopsis thaliana GSK3's, BIN2 & ASKα/ γ/ε/ζ/ι/θ, but not ASKβ/δ or three other Arabidopsis Ser/Thr kinases, AtMPK4, AtMPK6, and AtAURORA1. The inhibitory activity is plant species-selective, as Bikinin exhibits much reduced activity against human Gsk-3β, Aurora B, Aurora C (45.6%, 69.4%, and 42.8% inhibition, respectively, with 10 µM Bikinin), and little or no activity against 74 other human kinases, nor does it affect GSK-3β-mediated dorsoventral axis formation during Xenopus embryo development. Bikinin at 30 µM is shown to bypass brassinolide (BL) and BRI1 and effectively activate brassinosteroid (BR) signaling responses in Arabidopsis thaliana seedings, including decreased BES1 phosphorylation, increased hypocotyl length, long and bending petioles, blade-shaped, pale-green leaves, as well as reduced lateral root density.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number188011-69-0
Chemical formulaC₉H₉BrN₂O₃
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesRybel, B.D., et al. 2009. Chem. Biol. 16, 594.