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200498 Betulinic Acid - CAS 472-15-1 - Calbiochem

Antitumor and anti-HIV agent.

Betulinic Acid - CAS 472-15-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3β-Hydroxy-20(29)-lupaene-28-oic Acid

Primary Target: Inhibits human melanoma in cell culture and in animal models
200498
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
472-15-1C₃₀H₄₈O₃
Description
Overview

This product has been discontinued.



Antitumor and anti-HIV agent. A pentacyclic triterpene that selectively inhibits human melanoma in cell culture and in animal models. Appears to act specifically on melanoma cells without affecting other types of tumors. The antitumor effects of betulinic acid appear to be associated with the induction of mitochondrial permeability transition pore that triggers apoptosis. Also acts as a potent inhibitor of Hh/Gli signaling pathway inhibitor (IC50 = 32 µM).
Catalogue Number200498
Brand Family Calbiochem®
Synonyms3β-Hydroxy-20(29)-lupaene-28-oic Acid
References
ReferencesHollis, A., et al. 2012. ChemBioChem> in press.
Arai, M.A., et al. 2008. Bioorg. Med. Chem. 18, In press.
Fulda, S., et al. 1998. J. Biol. Chem. 273, 33942.
Rieber, M. and Strasberg-Reiber, M., et al. 1998. DNA Cell. Biol. 17, 399.
Kashiwada, Y., et al. 1996. J. Med. Chem. 39, 1016.
Pisha, E., et al. 1995. Nat. Med. 1, 1046.
Recio, M.C., et al. 1995. Planta Med. 61, 9.
Fujioka, T., et al. 1994. J. Nat. Prod. 57, 243.
Product Information
CAS number472-15-1
ATP CompetitiveN
FormColorless solid
Hill FormulaC₃₀H₄₈O₃
Chemical formulaC₃₀H₄₈O₃
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetInhibits human melanoma in cell culture and in animal models
Primary Target IC<sub>50</sub>32 µM inhibiting Hh/Gli signaling pathway
Purity>97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
200498 0

Documentation

Betulinic Acid - CAS 472-15-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Betulinic Acid - CAS 472-15-1 - Calbiochem Certificates of Analysis

TitleLot Number
200498

References

Hivatkozások áttekintése
Hollis, A., et al. 2012. ChemBioChem> in press.
Arai, M.A., et al. 2008. Bioorg. Med. Chem. 18, In press.
Fulda, S., et al. 1998. J. Biol. Chem. 273, 33942.
Rieber, M. and Strasberg-Reiber, M., et al. 1998. DNA Cell. Biol. 17, 399.
Kashiwada, Y., et al. 1996. J. Med. Chem. 39, 1016.
Pisha, E., et al. 1995. Nat. Med. 1, 1046.
Recio, M.C., et al. 1995. Planta Med. 61, 9.
Fujioka, T., et al. 1994. J. Nat. Prod. 57, 243.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-January-2012 JSW
Synonyms3β-Hydroxy-20(29)-lupaene-28-oic Acid
DescriptionAnti-tumor and anti-HIV agent. A pentacyclic triterpene that has been shown to selectively inhibit human melanoma in cell culture and animal models. Appears to act specifically on melanoma cells without affecting other types of tumors. The anti-tumor activity of betulinic acid appears to be mediated by the induction of apoptosis. Also acts as a potent inhibitor of Hh/Gli signaling pathway inhibitor (IC50 = 32 µM). Selectively inhibits DNA binding of C/EBPs (IC50 = 13.4, 38, 10.8, 10.7 and 8.0 µM against C/EBPα, C/EBPβ, C/EBPγ C/EBPδ and C/EBPε, respectively).
FormColorless solid
CAS number472-15-1
Chemical formulaC₃₀H₄₈O₃
Structure formulaStructure formula
Purity>97% by HPLC
SolubilityDMSO (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHollis, A., et al. 2012. ChemBioChem> in press.
Arai, M.A., et al. 2008. Bioorg. Med. Chem. 18, In press.
Fulda, S., et al. 1998. J. Biol. Chem. 273, 33942.
Rieber, M. and Strasberg-Reiber, M., et al. 1998. DNA Cell. Biol. 17, 399.
Kashiwada, Y., et al. 1996. J. Med. Chem. 39, 1016.
Pisha, E., et al. 1995. Nat. Med. 1, 1046.
Recio, M.C., et al. 1995. Planta Med. 61, 9.
Fujioka, T., et al. 1994. J. Nat. Prod. 57, 243.