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197332 Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione

Primary Target: Bcl-2
197332
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
141266-44-6C₁₅H₉ClN₄O₆
Description
Overview

This product has been discontinued.



A cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
Catalogue Number197332
Brand Family Calbiochem®
Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
References
ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.
Product Information
CAS number141266-44-6
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₅H₉ClN₄O₆
Chemical formulaC₁₅H₉ClN₄O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBcl-2
Purity≥95% by elemental analysis
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
197332 0

Documentation

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Bcl-2 Inhibitor III, EM20-25 - CAS 141266-44-6 - Calbiochem Certificates of Analysis

TitleLot Number
197332

References

Hivatkozások áttekintése
Milanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms5-(6-Chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diaza-anthracen-10-yl)-pyrimidine-2,4,6-trione
DescriptionA cell-permeable pyrimidine-trione compound that sensitizes apoptosis-resistant, Bcl-2-overexpressing leukemic cells to cytotoxic drugs. Shown to bind to Bcl-2, disrupt its interaction with Bax, and activate caspase-9. Also induces PTP (permeability transition pore) opening in both isolated mitochondria and intact cells, without any effect on respiration.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number141266-44-6
Chemical formulaC₁₅H₉ClN₄O₆
Structure formulaStructure formula
Purity≥95% by elemental analysis
SolubilityDMSO (2 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
ReferencesMilanesi, E., et al. 2006. J. Biol. Chem. 281, 10066.