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196806 Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-3,6-Dibromo-9-(2-fluoro-3-piperazin-1-yl-propyl)-carbazole, 2HCl, MAC Inhibitor II

196806
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
335166-00-2C₁₉H₂₀Br₂FN₃ •2HCl
Description
Overview

This product has been discontinued.



A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 µM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 µM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 µM).
Catalogue Number196806
Brand Family Calbiochem®
Synonyms(±)-3,6-Dibromo-9-(2-fluoro-3-piperazin-1-yl-propyl)-carbazole, 2HCl, MAC Inhibitor II
References
ReferencesPeixoto, P.M., et al. 2009. Biochem. J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
Product Information
CAS number335166-00-2
FormOff-white solid
Hill FormulaC₁₉H₂₀Br₂FN₃ •2HCl
Chemical formulaC₁₉H₂₀Br₂FN₃ •2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
196806 0

Documentation

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Certificates of Analysis

TitleLot Number
196806

References

Hivatkozások áttekintése
Peixoto, P.M., et al. 2009. Biochem. J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
Synonyms(±)-3,6-Dibromo-9-(2-fluoro-3-piperazin-1-yl-propyl)-carbazole, 2HCl, MAC Inhibitor II
DescriptionA MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 µM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 µM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number335166-00-2
Chemical formulaC₁₉H₂₀Br₂FN₃ •2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPeixoto, P.M., et al. 2009. Biochem. J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.