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203715 BQ-610 - Calbiochem

A highly selective ETA receptor antagonist (IC₅₀ = 20 nM) that attenuates ET-induced reduction in cardiac output.

BQ-610 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: ETA receptor antagonist
203715
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Empirical Formula
C₃₆H₄₇N₇O₆
Description
Overview

This product has been discontinued.



A highly selective ETA receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50 = 28.2 nM). BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in porcine aortic smooth muscle membrane assay.
Catalogue Number203715
Brand Family Calbiochem®
References
ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
Product Information
ATP CompetitiveN
FormWhite lyophilized powder
FormulationSupplied as an ammonium salt.
Hill FormulaC₃₆H₄₇N₇O₆
Chemical formulaC₃₆H₄₇N₇O₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetETA receptor antagonist
Primary Target IC<sub>50</sub>20 nM as ETA receptor antagonist that attenuates ET-induced reduction in cardiac output
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
203715 0

Documentation

BQ-610 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

BQ-610 - Calbiochem Certificates of Analysis

TitleLot Number
203715

References

Hivatkozások áttekintése
Beyer, M.E., et al. 1999. Hypertension 33, 145.
Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-April-2010 JSW
DescriptionA highly selective endothelin A (ETA) receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Inhibits ET-1 induced mitogenesis in airway smooth muscle cells in a concentration-dependent manner (IC50 = 20 nM). Also inhibits ET-1 and ET-3 induced activation of adenylate cyclase (IC50 = 28.2 nM). Has been shown to prevent endothelin-induced vasoconstriction. BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in a porcine aortic smooth muscle assay.
FormWhite lyophilized powder
FormulationSupplied as an ammonium salt.
Chemical formulaC₃₆H₄₇N₇O₆
Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
Purity≥90% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.