196870 Sigma-AldrichBAY 11-7082 - CAS 19542-67-7 - Calbiochem
BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
More>> BAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules. Less<<Synonyms: (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
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Áttekintés
Kulcsspecifikációk táblázata
CAS # | Empirical Formula |
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19542-67-7 | C₁₀H₉NO₂S |
Products
Katalógusszám | Csomagolás | Menny./csomag | |
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196870-10MG | Üvegpalack | 10 mg |
Description | |
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Overview | Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available. |
Catalogue Number | 196870 |
Brand Family | Calbiochem® |
Synonyms | (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile |
References | |
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References | Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096. |
Product Information | |
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CAS number | 19542-67-7 |
Form | Off-white solid |
Hill Formula | C₁₀H₉NO₂S |
Chemical formula | C₁₀H₉NO₂S |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | TNF-α-inducible phosphorylation of IκBα |
Primary Target IC<sub>50</sub> | 10 µM inhibiting TNF-α-inducible phosphorylation of IκBα |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Katalógusszám | GTIN |
196870-10MG | 04055977206562 |