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196870 BAY 11-7082 - CAS 19542-67-7 - Calbiochem

196870
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
19542-67-7C₁₀H₉NO₂S

Products

KatalógusszámCsomagolás Menny./csomag
196870-10MG Üvegpalack 10 mg
Description
OverviewPotential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
Catalogue Number196870
Brand Family Calbiochem®
Synonyms(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
References
ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Product Information
CAS number19542-67-7
FormOff-white solid
Hill FormulaC₁₀H₉NO₂S
Chemical formulaC₁₀H₉NO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationBAY 11-7082, CAS 19542-67-7, selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IBα (IC50 = 10 µM), resulting in reduced levels of NF-B. and of adhesion molecules.
Biological Information
Primary TargetTNF-α-inducible phosphorylation of IκBα
Primary Target IC<sub>50</sub>10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
196870-10MG 04055977206562