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ABS88 Anti-phospho-mTOR (Thr2164) Antibody

ABS88
100 µL  
Purchase on Sigma-Aldrich

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Species ReactivityKey ApplicationsHostFormatAntibody Type
HDB, WBRbSerumPolyclonal Antibody
Description
Catalogue NumberABS88
DescriptionAnti-phospho-mTOR (Thr2164) Antibody
Alternate Names
  • Serine/threonine-protein kinase mTOR
  • FK506-binding protein 12-rapamycin complex-associated protein 1
  • FKBP12-rapamycin complex-associated protein
  • Mammalian target of rapamycin
  • mTOR
  • Mechanistic target of rapamycin
  • Rapamycin and FKBP12 target 1
  • Rapamycin target protein 1
Background InformationThe mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer.
Product Information
FormatSerum
Control
  • Unmodified and phosphorylated mTOR peptides
PresentationRabbit polyclonal serum containing 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-mTOR Antibody is an antibody against phospho-mTOR (Thr2164) for use in Dot Blot, Western Blotting.
Key Applications
  • Dot Blot
  • Western Blotting
Application NotesWestern Blot Analysis: A representative lot was used by an independent laboratory in HEK293 cell lysate. (Ekim, B., et al. (2011). MCB. [Epub ahead of print].)
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human mTOR phosphorylated at Thr2164.
EpitopePhosphorylated Thr2164
HostRabbit
SpecificityThis antibody recognizes mTOR phosphorylated at Thr2164.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • MTOR
  • FRAP
  • FRAP1
  • FRAP2
  • RAFT1
  • RAPT1
Purification MethodUnpurified
UniProt Number
Molecular Weight289 kDa calculated
Product Usage Statements
Quality AssuranceDot Blot Specificity Analysis: Unmodified and phosphorylated mTOR peptides were probed with Anti-phospho-mTOR (Thr2164) (1:1,000 dilution).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Global Trade Item Number
Katalógusszám GTIN
ABS88 04053252696695