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AB8123 Anti-phospho-Integrin β1 (Thr788/789) Antibody

This Anti-phospho-Integrin β1 (Thr788/789) Antibody is validated for use in WB for the detection of phospho-Integrin β1 (Thr788/789).

Anti-phospho-Integrin β1 (Thr788/789) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Integrins Gene Symbol: ITGB1, GPIIA, OTTHUMP00000063731, OTTHUMP00000046253, OTTHUMP00000063733, VLAB, OTTHUMP00000063732, MDF2, FNRB, CD29, MSK12 UniProt Number: P05556
AB8123
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Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB8123
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-phospho-Integrin β1 (Thr788/789) Antibody
References
Product Information
FormatSerum
PresentationRaw Rabbit Serum with 0.1% Sodium Azide
Quality LevelMQ100
Applications
ApplicationThis Anti-phospho-Integrin β1 (Thr788/789) Antibody is validated for use in WB for the detection of phospho-Integrin β1 (Thr788/789).
Key Applications
  • Western Blotting
Biological Information
ImmunogenC-terminal Peptide
HostRabbit
SpecificityIntegrin B1 phosphorylated on Thr788/789
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryIntegrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene.
Gene Symbol
  • ITGB1
  • GPIIA
  • OTTHUMP00000063731
  • OTTHUMP00000046253
  • OTTHUMP00000063733
  • VLAB
  • OTTHUMP00000063732
  • MDF2
  • FNRB
  • CD29
  • MSK12
Modifications
  • Phosphorylation
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P05556 # Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.


SIZE: 798 amino acids; 88465 Da

SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha- 5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with FLNA. Binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5 (By similarity). Interacts with FLNB and RANBP9. Isoform Beta-1D interacts with ACE2. Isoform Beta-1A interacts with the C-terminal region of FLNC. Interacts with HIV-1 Tat.

SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Isoform beta-1B does not localize to focal adhesions. Highly enriched in stage I melanosomes.

TISSUE SPECIFICITY: Isoform beta-1A is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform beta-1B is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbelical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform beta-1C and isoform beta-1C-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-C-2, rather than isoform beta-1C, is selectively expressed in primary T-cells. Isoform beta-1C is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1D is expressed specifically in striated muscle (skeletal and cardiac muscle).





SIMILARITY: SwissProt: P05556 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain.
Molecular Weight120kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at 4°C from date of shipment
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
AB8123 04053252673917

Documentation

Anti-phospho-Integrin β1 (Thr788/789) Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-phospho-Integrin β1 (Thr788/789) Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) -2749209 2749209
RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) -2804187 2804187
RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY 2879606
RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY -2506066 2506066

References

Reference overviewPub Med ID
Deletion of core fucosylation on alpha3beta1 integrin down-regulates its functions
Zhao, Yanyang, et al
J Biol Chem, 281:38343-50 (2006)  2005

17043354 17043354
Epidermal Growth Factor Signaling for Matrix-Dependent Cell Proliferation and Differentiation in Primary Cultured Hepatocytes
Kim, Sang-Heon and Akaike, Toshihiro
Kim, Sang-Heon and Akaike, Toshihiro  2005

17198484 17198484

Data Sheet

Title
RABBIT ANTI-PHOSPHO INTEGRIN B1 (Thr788/789) POLYCLONAL ANTIBODY