Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

OP19 Anti-c-Abl (Ab-2) Mouse mAb (19-110)

Anti-c-Abl (Ab-2) Mouse mAb (19-110) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Anti-p150, Anti-Abl

OP19
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Species ReactivityHostAntibody Type
H, MMMonoclonal Antibody
Description
Overview

This product has been discontinued.



Recognizes the ~145 kDa human c-Abl, the ~150 kDa mouse c-Abl, v-Abl proteins, and the Bcr/Abl translocation products in ALL (~190 kDa) and CML (~210 kDa).

  • Antibody Target Gene Symbol: ABL1
  • Target Synonym: ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl
  • Entrez Gene Name: c-abl oncogene 1, receptor tyrosine kinase
  • Hu Entrez ID: 25 (Related Antibodies: OP20 PK1006 PK1013)
  • Mu Entrez ID: 11350
  • Rat Entrez ID: 311860
    		•
    Catalogue NumberOP19
    Brand Family Calbiochem®
    SynonymsAnti-p150, Anti-Abl
    References
    ReferencesWiedemann, L.M., et al. 1988. Blood 71, 349.
    Schiff-Maker, L., Buet al. 1986. J. Virol. 57, 1182.
    Stam, K., et al. 1985. N. Engl. J. Med. 313, 1429.
    Konopka, J.B., et al. 1984. Cell 37, 1035.
    Prywes, R., et al. 1983. Cell 34, 569.
    de Klein, et al. 1982. Nature 300, 765. 1982.
    Reynolds, F.H., et al. 1980. J. Virol. 36, 374.
    Reynolds, F.H., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 3974.
    Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 2488. 1978.
    Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res. 30, 2213.
    Product Information
    FormLiquid
    FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin.
    Positive controlK562 (human bcr/abl protein), ANN-1 (mouse abl protein), HL-60 (human normal abl protein), or NIH 3T3 (mouse normal abl protein) cells
    Preservative≤0.1% sodium azide
    Quality LevelMQ100
    Applications
    Application ReferencesNeutralization Studies, Original Clone Schiff-Maker, L., Buet al. 1986. J. Virol. 57, 1182.
    Key Applications Immunoblotting (Western Blotting)
    Immunoprecipitation
    Neutralization Studies
    Application NotesImmunoblotting (1-5 µg/ml)
    Immunoprecipitation (1-2 µg/sample)
    Neutralization Studies (see application references)
    Application CommentsInhibits tyrosine kinase activity (see application references). Antibody should be titrated for optimal use in individual systems.
    Biological Information
    Immunogena TrpE-v-Abl fusion protein
    Clone19-110
    HostMouse
    IsotypeIgG₁
    Species Reactivity
    • Human
    • Mouse
    Antibody TypeMonoclonal Antibody
    Concentration Label Please refer to vial label for lot-specific concentration
    Physicochemical Information
    Dimensions
    Materials Information
    Toxicological Information
    Safety Information according to GHS
    Safety Information
    Product Usage Statements
    Storage and Shipping Information
    Ship Code Blue Ice Only
    Toxicity Standard Handling
    Storage +2°C to +8°C
    Do not freeze Yes
    Packaging Information
    Transport Information
    Supplemental Information
    Specifications
    Global Trade Item Number
    Katalógusszám GTIN
    OP19 0

    Documentation

    Anti-c-Abl (Ab-2) Mouse mAb (19-110) MSDS

    Title

    Safety Data Sheet (SDS) 

    Anti-c-Abl (Ab-2) Mouse mAb (19-110) Certificates of Analysis

    TitleLot Number
    OP19

    References

    Hivatkozások áttekintése
    Wiedemann, L.M., et al. 1988. Blood 71, 349.
    Schiff-Maker, L., Buet al. 1986. J. Virol. 57, 1182.
    Stam, K., et al. 1985. N. Engl. J. Med. 313, 1429.
    Konopka, J.B., et al. 1984. Cell 37, 1035.
    Prywes, R., et al. 1983. Cell 34, 569.
    de Klein, et al. 1982. Nature 300, 765. 1982.
    Reynolds, F.H., et al. 1980. J. Virol. 36, 374.
    Reynolds, F.H., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 3974.
    Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 2488. 1978.
    Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res. 30, 2213.

    Brochure

    Title
    Antibody Sourcebookﾙ Sixth Edition
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision26-February-2008 JSW
    SynonymsAnti-p150, Anti-Abl
    ApplicationImmunoblotting (1-5 µg/ml)
    Immunoprecipitation (1-2 µg/sample)
    Neutralization Studies (see application references)
    DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specifed immunogen and fusing splenocytes with P.3U1 mouse myeloma cells (see application references). Recognizes the v-abl, CML c-brc/abl p210, human ALL c-brc/abl p190, human c-abl p145, and mouse c-abl p150 proteins.
    BackgroundThe abl oncogene was initially identified as the viral transforming gene (v-abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M-MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of gag/c-abl tyrosine kinases, phosphoproteins p160 and p120, as the major translational products. The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL) and 2-5% of pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22. The molecular consequences of this translocation are the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.
    HostMouse
    Immunogena TrpE-v-Abl fusion protein
    Clone19-110
    IsotypeIgG₁
    Specieshuman, mouse
    Positive controlK562 (human bcr/abl protein), ANN-1 (mouse abl protein), HL-60 (human normal abl protein), or NIH 3T3 (mouse normal abl protein) cells
    FormLiquid
    FormulationIn 50 mM sodium phosphate buffer, 0.2% gelatin.
    Concentration Label Please refer to vial label for lot-specific concentration
    Preservative≤0.1% sodium azide
    CommentsInhibits tyrosine kinase activity (see application references). Antibody should be titrated for optimal use in individual systems.
    Storage +2°C to +8°C
    Do Not Freeze Yes
    Toxicity Standard Handling
    ReferencesWiedemann, L.M., et al. 1988. Blood 71, 349.
    Schiff-Maker, L., Buet al. 1986. J. Virol. 57, 1182.
    Stam, K., et al. 1985. N. Engl. J. Med. 313, 1429.
    Konopka, J.B., et al. 1984. Cell 37, 1035.
    Prywes, R., et al. 1983. Cell 34, 569.
    de Klein, et al. 1982. Nature 300, 765. 1982.
    Reynolds, F.H., et al. 1980. J. Virol. 36, 374.
    Reynolds, F.H., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 3974.
    Witte, O.N., et al. 1978. Proc. Natl. Acad. Sci. USA 75, 2488. 1978.
    Abelson, H.T. and Rabstein, L.S. 1970. Cancer Res. 30, 2213.
    Application referencesNeutralization Studies, Original Clone Schiff-Maker, L., Buet al. 1986. J. Virol. 57, 1182.