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AB2265 Anti-VPAC1 Antibody

Anti-VPAC1 Antibody detects level of VPAC1 & has been published & validated for use in IH(P) & WB.

Anti-VPAC1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Hormones & Receptors Gene Symbol: VIPR1, PACAP-R-2, RCD1, VIP-R-1, VPAC1, VIRG, HVR1, VPCAP1R, VAPC1, VIPR, RDC1 UniProt Number: P97751
AB2265
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIH(P), WBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB2265
DescriptionAnti-VPAC1 Antibody
Alternate Names
  • Vasoactive intestinal polypeptide receptor 1
  • Pituitary adenylate cyclase-activating polypeptide type II receptor
  • vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1
Background InformationThe vasoactive intestinal peptide/pituitary adenylate cyclase activating peptide receptor 1 (VPAC1) is a member of a class II subfamily of G-protein-coupled receptors and has a high affinity for vasoactive intestinal peptide (VIP). VPAC1 has been associated with many different lung cancer cell lines. VPAC1 is thought to be activated by FXR and may contribute to the regulation of bile secretion to protect against gallstone disease. VPAC1 could be used to regulate VIPs and, in turn, inhibit breast cancer growth. VPAC1 has also been implicated in regulation of the anti-inflammatory effects of VIP.
References
Product Information
FormatAffinity Purified
Control
  • SK-OV-3 cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-VPAC1 Antibody detects level of VPAC1 & has been published & validated for use in IH(P) & WB.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application NotesImmunohistochemistry Analysis: 1:500 dilution from a previous lot detected VPAC1 in ovarian carcinoma tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the cytoplasmic domain of VPAC1.
EpitopeCytoplasmic domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes VPAC1 at the cytoplasmic domain.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • VIPR1
  • PACAP-R-2
  • RCD1
  • VIP-R-1
  • VPAC1
  • VIRG
  • HVR1
  • VPCAP1R
  • VAPC1
  • VIPR
  • RDC1
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 2 family.
Molecular Weight~52 kDa observed. Multiple molecular weights of VPAC1 may be due to glycosylation. (Fabre, C, et al. (1993). Peptides. 14:483-489.)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in SK-OV-3 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected VPAC1 on 10 µg of SK-OV-3 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
AB2265 04053252415692