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MABS466 Anti-Trpv4 Antibody, clone 1B2.6

Anti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.

Anti-Trpv4 Antibody, clone 1B2.6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: VRL2, VROAC, TRPV4 UniProt Number: Q9HBA0
MABS466
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS466
DescriptionAnti-Trpv4 Antibody, clone 1B2.6
Alternate Names
  • Trpv4
  • Transient receptor potential cation channel subfamily V member 4
  • TrpV4
  • Osm-9-like TRP channel 4
  • OTRPC4
  • Transient receptor potential protein 12
  • TRP12
  • Vanilloid receptor-like channel 2
  • Vanilloid receptor-like protein 2
  • VRL-2
  • Vanilloid receptor-related osmotically-activated channel
  • VR-OAC
Background InformationTransient receptor potential cation channel subfamily V member 4 is a multitransmembrane non-selective cation channel encoded by the TRPV4 (also known as CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VR-OAC, VRL-2, VRL2, VROAC) gene and belong to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the transient receptor potential (TRP)3 superfamily of channels. Ankyrin (ANK) repeats/domains are shown to be important for functional channel expression, and ANK domain mutations are found in patients suffering from Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and hereditary motor and sensory neuropathies (HMSN). (PMID 16293632, 20037587, 20037588).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Trpv4 Antibody, clone 1B2.6 is an antibody against Trpv4 for use in Western Blotting and Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry Analysis: 10 µg/mL from a representative lot detected Trpv4 in NIH/3T3 cells.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to human Trpv4.
Clone1B2.6
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityThis antibody is expected to react to all isoforms.
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • VRL2
  • VROAC
  • TRPV4
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~86-98 kDa observed. Uniprot describes 6 isoforms produced by alternative splicing ranging from ~86 to 98 kDa. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SK-MEL-28 cell lysate.

Western Blotting Analysis: 0.1 µg/mL of this antibody detected Trpv4 in 10 µg of SK-MEL-28 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MABS466 04055977145021

Documentation

Anti-Trpv4 Antibody, clone 1B2.6 Certificates of Analysis

TitleLot Number
Anti-Trpv4, clone 1B2.6 - 3182595 3182595
Anti-Trpv4, clone 1B2.6 - 3224555 3224555
Anti-Trpv4, clone 1B2.6 - 3462069 3462069
Anti-Trpv4, clone 1B2.6 - 3781059 3781059
Anti-Trpv4, clone 1B2.6 - 3822336 3822336
Anti-Trpv4, clone 1B2.6 - 4095326 4095326
Anti-Trpv4, clone 1B2.6 -2891852 2891852
Anti-Trpv4, clone 1B2.6 -Q2559148 Q2559148
Anti-Trpv4, clone 1B2.6 Monoclonal Antibody 3101501
Anti-Trpv4, clone 1B2.6 Monoclonal Antibody MABS466
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Technical Info

Title
White Paper: Further considerations of antibody validation and usage.