Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABS165 Anti-STAM-binding protein Antibody, clone 4D12.2

This Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.

Anti-STAM-binding protein Antibody, clone 4D12.2 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: AMSH, STAMBP UniProt Number: O95630
MABS165
100 µg  
Purchase on Sigma-Aldrich

Különleges ajánlatok

Áttekintés

Replacement Information

Különleges ajánlatok

100% Performance Guaranteed

Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS165
DescriptionAnti-STAM-binding protein Antibody, clone 4D12.2
Alternate Names
  • STAMBP
  • STAM-binding protein
  • Associated molecule with the SH3 domain of STAM
  • Endosome-associated ubiquitin isopeptidase
  • AMSH
Background InformationSTAM-binding protein (STAMBP) is a critical metalloprotease in ubiquitin-mediated signaling events that specifically cleaves 'Lys-63'-linked polyubiquitin chains but does not cleave 'Lys-48'-linked polyubiquitin chains. STAM-binding protein is a deubiquitinating (DUB) isopeptidase also known as AMSH, for associated molecule with the SH3 domain of STAM. STAM-binding protein plays a role in cell growth and MYC induction, potentiates BMP signaling and is key in regulating the cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. STAM-binding protein interacts with other key proteins including STAM1, SMAD6/7, SMURF2, and CHMP3. STAM-binding protein is widely expressed and can be found localized to the nucleus, cytoplasm and endosome. Defects in STAM-binding protein result in a congenital syndrome named Microcephaly-capillary malformation syndrome.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesImmunocytochemistry analysis: 1:50 dilution from a representative lot detected STAM binding protein in A431 cells
DyLight™ is a trademark of Thermo Fisher Scientific, Inc. and its subsidiaries.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to Human STAM-binding protein.
Clone4D12.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • AMSH
  • STAMBP
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~50 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by western blotting on Jurkat cell lysate
Western Blotting Analysis: 1 µg/mL of this antibody detected STAM binding protein in 10 µg of Jurkat cell lysate
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MABS165 04053252984990