Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

05-1109 Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01

05-1109
1 mg  
Purchase on Sigma-Aldrich

Különleges ajánlatok

Áttekintés

Replacement Information

Különleges ajánlatok

Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)MPurifiedMonoclonal Antibody
Description
Catalogue Number05-1109
ReplacesCBL94
DescriptionAnti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01
Alternate Names
  • CD220 antigen
  • insulin receptor
Background InformationPro-Insulin consists of the three parts: C-peptide and two long strands of amino acids (alpha and beta chains; later become linked together to form the Insulin molecule). From every molecule of Pro-Insulin, one molecule of Insulin plus one molecule of C-peptide are produced. C-peptide is released into the blood stream in equal amounts to Insulin.
References
Product Information
FormatPurified
Control
  • Human normal pancreas tissue
PresentationMouse monoclonal IgG1 in phosphate buffered saline, pH7.4, and 15 mM sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 is validated for use in IH(P) for the detection of Pro-Insulin C-Peptide.
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenSynthetic C-peptide of human pro-insulin conjugated to bovine serum albumin.
CloneC-PEP-01
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThe antibody C-PEP-01 reacts specifically with C-peptide, a part of the Pro-insulin molecule.
IsotypeIgG1
Species Reactivity
  • Human
Species Reactivity NoteReacts with human. No cross-reactivity with Insulin or other peptide hormones or proteins was observed.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ILPR
  • IRDN
  • OTTHUMP00000011161
  • OTTHUMP00000011162
  • OTTHUMP00000196038
  • insulin
  • proinsulin
Purification MethodSequential precipitation with caprylic acid and ammonium sulfate.
UniProt Number
UniProt SummaryFUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
SUBUNIT STRUCTURE: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
SUBCELLULAR LOCATION: Secreted.
INVOLVEMENT IN DISEASE: Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
PHARMACEUTICAL USE: Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53.
SEQUENCE SIMILARITIES: Belongs to the insulin family.
SEQUENCE CAUTION: The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Molecular WeightApprox. 12 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in normal human pancreas.
Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected insulin in human normal pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at 2-8°C and use within 1 year from date of receipt.
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
05-1109 04053252676529

Documentation

Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 MSDS

Title

Safety Data Sheet (SDS) 

Anti-Pro-Insulin C-Peptide Antibody, clone C-PEP-01 Certificates of Analysis

TitleLot Number
Anti-Pro-Insulin C-Peptide, clone C-PEP-01 - 2430453 2430453
Anti-Pro-Insulin C-Peptide, -2585775 2585775
Anti-Pro-Insulin C-Peptide, -2586148 2586148
Anti-Pro-Insulin C-Peptide, -2611648 2611648
Anti-Pro-Insulin C-Peptide, -2611775 2611775
Anti-Pro-Insulin C-Peptide, -2626026 2626026
Anti-Pro-Insulin C-Peptide, -2649099 2649099
Anti-Pro-Insulin C-Peptide, -2721692 2721692
Anti-Pro-Insulin C-Peptide, clone C-PEP-01 3062760
Anti-Pro-Insulin C-Peptide, clone C-PEP-01 - 1977635 1977635

References

Reference overviewPub Med ID
Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells.
Yamada, Mitsutoshi, et al.
Nature, (2014)  2014

Kivonat megmutatása
24776804 24776804
iPSC-derived β cells model diabetes due to glucokinase deficiency.
Hua, H; Shang, L; Martinez, H; Freeby, M; Gallagher, MP; Ludwig, T; Deng, L; Greenberg, E; Leduc, C; Chung, WK; Goland, R; Leibel, RL; Egli, D
The Journal of clinical investigation  123  3146-53  2013

Kivonat megmutatása
23778137 23778137

Brochure

Title
Product Selection Guide - Antibodies, small molecule inhibitors, kits, assays and proteins for signaling research.