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ABC331 Anti-PALB2 Antibody

Anti-PALB2 Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC.

Anti-PALB2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PALB2 UniProt Number: Q86YC2
ABC331
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC331
DescriptionAnti-PALB2 Antibody
Alternate Names
  • Partner and localizer of BRCA2
  • FANCN
Background InformationPartner and localizer of BRCA2 (PALB2) is the critical protein required for the homologous recombination repair at DNA breaks. It serves as a scaffold protein in the formation of the BRAC1-PALB2-BRAC2 complex which is essential for homologous recombination. Essentially a partner of BRAC2, PALB2 localizes BRAC2 and stabilizes it. PALB2 enables BRAC2 to perform its recombinational repair and checkpoint functions in addition to its DNA repair functions. Also by binding BRAC2, PALB2 is thought to help BRCA2 avoid degradation. PALB2 localizes to the nucleus and has at least four known isoforms. Defects in PALB2 are linked with many forms of breast cancers, pancreatic cancer type 3 (PNCA3), as well as disorders of the bone marrow (Fanconi anemia complementation group, FANCN). These patients suffer numerous cardiac, limb, and skin malformations as well as malignancies. EMD Millipore’s Anti-PALB2 rabbit polyclonal antibody has been tested in western blotting in human SK-N-SH cell lysate samples.
References
Product Information
FormatAffinity Purified
Control
  • SK-N-SH cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-PALB2 Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected SPALB2 in human breast cancer tissue.

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PALB2.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • PALB2
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~180 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SK-N-SH cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected PALB2 in 15 µg of SK-N-SH cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
ABC331 04053252917387