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AB5511 Anti-Opioid Receptor Antibody, µ, pain

AB5511
50 µL  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, R, PmICC, IHC, WBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB5511
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Opioid Receptor Antibody, µ, pain
Alternate Names
  • mu opiate receptor
  • opioid receptor
  • mu 1
Background InformationOpiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002).
Product Information
FormatSerum
Control
  • Spinal cord, liver lysate
PresentationRabbit polyclonal serum in buffer containing 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blotting
Application NotesImmunohistochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.

Western blot:
1:1,000 dilution of a previous lot was used.

Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide from the C-terminus of rat Mu Opioid receptor.
EpitopeC-terminus
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityMu Opioid receptor.
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Primate
Species Reactivity NoteHuman, rat, mouse and primate. Other species have not been tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • OPRM1
  • MOR
  • MOR-1
  • MOR1
  • OPRM
  • KIAA0403
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P35372 # Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.
SIZE: 400 amino acids; 44779 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P35372 ## Belongs to the G-protein coupled receptor 1 family.
Molecular Weight45 kDa
Product Usage Statements
Quality AssuranceEvaluated by Western Blot on Human Liver lysate.

Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20ºC from date of receipt.
Packaging Information
Material Size50 µL
Global Trade Item Number
Katalógusszám GTIN
AB5511 04053252732508