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ABN417 Anti-ORMDL3 Antibody

Anti-ORMDL3 Antibody detects level of ORMDL3 & has been published & validated for use in ORMDL3.

Anti-ORMDL3 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: ORMDL3 UniProt Number: Q8N138
ABN417
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN417
DescriptionAnti-ORMDL3 Antibody
Alternate Names
  • ORM1-like protein 3
Background InformationThe protein named ORM1-like protein 3 (ORMDL3), and encoded by the human gene ORMDL3 belongs to a novel gene family of endoplasmic reticulum membrane proteins that are highly conserved and ubiquitously expressed in adult and fetal tissues. ORMDL3 is a negative regulator of sphingolipid biosynthesis and may indirectly regulate endoplasmic reticulum-mediated calcium signaling. Also in lung tissue, ORMDL3 is an inducible epithelial protein that regulates metalloproteases, chemokines, oligoadenylate synthetases and activates activating transcription factor 6 (ATF6), a critical protein in the unfolded protein response immune response pathway which plays an important role in our response to infections and pathology. The discovery of the link between ORMDL3 and the unfolded protein response pathway may be part of the mechanism of how ORMDL3 is involved in the asthmatic response and regulation. Defects and polymorphims in ORMDL3 gene are linked with Asthma and with asthmatic response profiles.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-ORMDL3 Antibody detects level of ORMDL3 & has been published & validated for use in ORMDL3.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected ORMDL3 in human thalamus and human lung tissue.
Biological Information
ImmunogenBlue carrier protein-conjugated linear peptide corresponding to human near C-Terminal of ORMDL3.
EpitopeNear C-Terminal
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Canine, Horse, Monkey based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • ORMDL3
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~19 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected ORMDL3 in 10 µg of human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
ABN417 04053252956737