Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB15518 Anti-Neuronal pentraxin 1 Antibody

This Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.

Anti-Neuronal pentraxin 1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: NPTX1, DKFZp686J2446, MGC105123, NP1, NP-I UniProt Number: Q15818
AB15518
50 µg  
Purchase on Sigma-Aldrich

Különleges ajánlatok

Áttekintés

Replacement Information

Különleges ajánlatok

100% Performance Guaranteed

Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
MELISA, WB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB15518
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Neuronal pentraxin 1 Antibody
Alternate Names
  • NPX1
Background InformationNeuronal Pentraxins: A new family of putative integral membrane pentraxins or Neuronal pentraxins identified through interaction with a presynaptic snake venom toxin taipoxin. NPX1, NPX2 and NPXR (Neuronal Pentraxin Receptor), the three neuronal pentraxins represent a novel neuronal uptake pathway that may function during synapse formation and remodeling. The N-terminal half of neuronal pentraxins are 20-30% identical to previously identified pentraxins (CRP and SAP), the three neuronal pentraxins are 50% identical to each other and are significantly larger than the classical pentraxins (>50 versus 30kDa), suggesting that they may have additional novel functions. NPX1(Neuronal Pentraxin 1) a 432aa protein in mouse and rat, 430aa in human (chr 17q25). It mediates the uptake of degraded synaptic material which could play an important role in synaptic remodeling, expressed in brain.
References
Product Information
FormatAffinity Purified
PresentationLiquid in PBS with 0.1% BSA.
Quality LevelMQ100
Applications
ApplicationThis Anti-Neuronal pentraxin 1 Antibody is validated for use in ELISA, WB, IH for the detection of Neuronal pentraxin 1.
Key Applications
  • ELISA
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern blot: 1-10 µg/mL using ECL.
Immunohistochemistry: Not tested. It is recommended that the antibody be tried at 2-20 µg/mL
ELISA: 0.5-1 µg/mL using control peptide.
Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenSynthetic peptide near the N-terminus of mouse NPX1
HostRabbit
SpecificityNeuronal pentraxin 1 (NPX1).
Species Reactivity
  • Mouse
Species Reactivity NoteThe immunogen sequence is 94% conserved in rat, and 82% in human NPX1.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryNPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.
Gene Symbol
  • NPTX1
  • DKFZp686J2446
  • MGC105123
  • NP1
  • NP-I
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q15818 # May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin (By similarity).
COFACTOR: Binds 2 calcium ions per subunit (By similarity).
SIZE: 432 amino acids; 47122 Da
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle (Potential).
SIMILARITY: SwissProt: Q15818 ## Contains 1 pentaxin domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
AB15518 04053252327377

Documentation

Anti-Neuronal pentraxin 1 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Neuronal pentraxin 1 Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-NEURONAL PENTRAXIN 1 - 3256014 3256014
RABBIT ANTI-NEURONAL PENTRAXIN 1 - 3257564 3257564
RABBIT ANTI-NEURONAL PENTRAXIN 1 - 3476021 3476021
RABBIT ANTI-NEURONAL PENTRAXIN 1 - 3614824 3614824
RABBIT ANTI-NEURONAL PENTRAXIN 1 - 3840814 3840814
RABBIT ANTI-NEURONAL PENTRAXIN 1 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3028823
RABBIT ANTI-NEURONAL PENTRAXIN 1 AFFINITY PURIFIED POLYCLONAL ANTIBODY 2987936
RABBIT ANTI-NEURONAL PENTRAXIN 1 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2329142 2329142
RABBIT ANTI-NEURONAL PENTRAXIN 1, AFFINITY PURIFIED, POLYCLONAL ANTIBODY 2829454

Data Sheet

Title
RABBIT ANTI-NEURONAL PENTRAXIN 1 AFFINITY PURIFIED