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MAB4162 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: ABCB1, PGY1, MGC163296, GP170, ABC20, CD243, P-gp, MDR1, CLCS, EC 3.6.3.44 UniProt Number: P08183
MAB4162
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
HFC, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB4162
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17
Alternate Names
  • P-glycoprotein
  • CD243
  • p170
  • Pgp
References
Product Information
FormatPurified
Control
  • MDR cells
PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Quality LevelMQ300
Applications
ApplicationAnti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 is an antibody against MDR1 for use in FC, IH.
Key Applications
  • Flow Cytometry
  • Immunohistochemistry
Application NotesFlow Cytometry

Immunohistochemistry on formalin fixed paraffin embedded sections

Confocal and Electron Microscopy

ELISA

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenLiving intact human multidrug-resistant cells
Epitopeextracellular human specific Pgp
CloneMM4.17
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes a mapped epitope in the extracellular Pgp domain and detects low-level Pgp expression in living (intact) human MDR cells (Cianfriglia, 2002). The epitope has been mapped to the single amino acid level using different techniques (Cianfriglia, 1994 and Poloni, 1995).
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Gene Symbol
  • ABCB1
  • PGY1
  • MGC163296
  • GP170
  • ABC20
  • CD243
  • P-gp
  • MDR1
  • CLCS
  • EC 3.6.3.44
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
SIZE: 1280 amino acids; 141463 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MAB4162 04053252660290

Documentation

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 MSDS

Title

Safety Data Sheet (SDS) 

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MM4.17 Certificates of Analysis

TitleLot Number
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] MONOCLONAL ANTIBODY - 2382133 2382133
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3548401 3548401
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] -2608421 2608421
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] -2726185 2726185
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] -2782647 2782647
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] MONOCLONAL ANTIBODY 3083843
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] MONOCLONAL ANTIBODY 3011396
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] MONOCLONAL ANTIBODY - 3933305 3933305

References

Reference overviewPub Med ID
Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer.
Yasunaga, M; Matsumura, Y
Scientific reports  4  4852  2014

Kivonat megmutatása 		24781822 24781822

Data Sheet

Title
Anti-MDR1, extracellular human specific Pgp, clone MM4.17 - Data Sheet