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MABN1587 Anti-MATR3 Antibody, clone 3G1.1

This Anti-MATR3 Antibody, clone 3G1.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of MATR3.

Anti-MATR3 Antibody, clone 3G1.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: MATR3, ALS21, KIAA0723, VCPDM UniProt Number: P43243
MABN1587
100 μg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN1587
DescriptionAnti-MATR3 Antibody, clone 3G1.1
Alternate Names
  • Matrin-3
Background InformationMatrin-3 (UniProt P43243) is encoded by the MATR3 (also known as ALS21, KIAA0723, VCPDM) gene (Gene ID 9782) in human. Matrin-3 is an inner nuclear matrix protein involved in multiple nuclear processes, including DNA double strand break response, DNA replication/repair, chromatin organization, and RNA stability and processing. Matrin-3 contains two RNA recognition motifs (a.a. 398-473/RRM1 and a.a. 496-571/RRM2) that mediate RNA-binding and a DNA-binding zinc finger motif (a.a. 801-832). Matrin-3 is known to interact with the RNA-binding protein TDP-43 and MATR3 gene mutations are linked to amyotrophic lateral sclerosis (ALS). Matrin-3 is also a known target of multiple alpha herpes viruses and is known to be utilized by HIV-1 as a Rev cofactor.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-MATR3 Antibody, clone 3G1.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of MATR3.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: An 1:250 dilution from a representative lot detected MATR3 in human cerebellum, human small intestine, and mouse cerebral cortex tissue sections.
Biological Information
ImmunogenGST-tagged recombinant internal fragment from the N-terminal half of human martin-3.
EpitopeInternal (N-terminal half).
Clone3G1.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityExpected to react with both spliced isoforms of human MATR3 reported by UniProt (P43243).
IsotypeIgG2bκ
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • MATR3
  • ALS21
  • KIAA0723
  • VCPDM
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~110 kDa observed. 94.62 kDa (isoform 1) and 62.58 kDa (isoform 2) calculated. The detected band size is consistent with the reported apparent molecular weight (Nakayasu, H., and Berezney, R. (1991). Proc. Natl. Acad. Sci. U. S. A. 88(22):10312-10316).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in SHSY-5Y cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MATR3 in 10 µg of SHSY-5Y cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MABN1587 04055977331257