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ABC74 Anti-IGPR-1 Antibody

Anti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.

Anti-IGPR-1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TMIGD2, IGPR1 UniProt Number: Q96BF3
ABC74
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
R, HWB, ICC, IHCRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABC74
DescriptionAnti-IGPR-1 Antibody
Alternate Names
  • Transmembrane and immunoglobulin domain-containing protein 2
  • Immunoglobulin and proline-rich receptor 1
  • IGPR-1
Background InformationIGPR-1 or Immunoglobulin and proline-rich receptor 1, also called Transmembrane and immunoglobulin domain-containing protein 2 and encoded by the human gene TMIGD2/IGPR1 is a widely expressed epithelial and endothelial membrane protein that plays a role in cell-cell interactions, cell migration and angiogenesis. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and in B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2.
References
Product Information
FormatPurified
PresentationPurified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-IGPR-1 antibody is an antibody against IGPR-1 for use in western blotting, ICC & IHC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected IGPR-1 in 10 µg of HepG2 cell lysate, human placenta tissue lysate, HUVEC cell lysate, and L9 cell lysate.

Western Blotting Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cell lysates (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

Immunocytochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in IGPR-1 transfected PAE cells (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected IGPR-1 in human colon cancer tissues (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.).
Biological Information
ImmunogenLinear peptide corresponding to the cytoplasmic domain of the human mature form of IGPR-1.
EpitopeCytoplasmic domain
Concentration1 mg/mL
HostRabbit
Species Reactivity
  • Rat
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TMIGD2
  • IGPR1
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~58 kDa observed. Uniprot describes two isoforms at 31 kDa and 30 kDa. The pre-mature and mature form of this protein may be observed at 32 kDa and 58 kDa (Rahimi, N., et al. (2012). Mol Cell Biol. 23(9):1646-1556.). Uncharacterized band(s) may be observed in some cell lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected IGPR-1 in 10 µg of PC-12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
ABC74 04053252970047