Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABN1456 Anti-IAPP

Anti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin).

Anti-IAPP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: IAPP UniProt Number: P10997
ABN1456
100 µL  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1456
DescriptionAnti-IAPP
Alternate Names
  • Amylin
  • Diabetes associated peptide
  • DAP
  • Insulinoma amyloid peptide
Background InformationIslet amyloid polypeptide (UniProt: P10997; also known as Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide, IAPP) is encoded by the IAPP gene (Gene ID: 3375) in human. IAPP is a secreted peptide that is degraded by insulin degrading enzyme (IDE). IAPP is a major constituent of amyloid deposits in pancreatic islets, characteristic histopathology for type 2 diabetes. The mature IAPP is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. In diabetic islets, water-soluble IAPP is shown to disappear in beta-cell granules and is transformed to water-insoluble amyloid deposits that can initiate beta cell necrosis. Oligomers of human IAPP can form toxic oligomers and induce apoptosis in cultured pancreatic cells. IAPP is shown to selectively inhibit insulin-stimulated glucose utilization and glycogen deposition in muscle, but does not affect adipocyte glucose metabolism. (Ref.: Bram, Y., et al. (2014). Scientific Reports 4, Article number: 4267; Tomita, T. (2012). Islets. 4(3): 223 232).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-IAPP, Cat. No. ABN1456, is a highly specific rabbit polyclonal antibody that targets Islet amyloid polypeptide and has been tested in Immunohistochemistry (Paraffin).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenA KLH-conjugated linear peptide from an internal region of human islet amyloid polypeptide.
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis polyclonal antibody detects IAPP in human pancreatic tissue.
Species Reactivity
  • Human
Species Reactivity NoteHuman.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • IAPP
Purification MethodAffinity Purified
UniProt Number
Molecular Weight9.8 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human pancreas tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IAPP in human pancreas tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
ABN1456 04054839153204