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MAB5628 Anti-Glial Fibrillary Acidic Protein Antibody

Detect Glial Fibrillary Acidic Protein using this Anti-Glial Fibrillary Acidic Protein Antibody validated for use in WB & IC.

Anti-Glial Fibrillary Acidic Protein Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuronal & Glial Markers Gene Symbol: GFAP, FLJ45472 UniProt Number: P14136
MAB5628
100 µg  
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Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, ICCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB5628
Replaces04-1031; 04-1062
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Glial Fibrillary Acidic Protein Antibody
Alternate Names
  • GFAP
Product Information
FormatPurified
Control
  • Positive: Neural tissue or astrocyte culture
    Negative: Non-neural tissue or neuronal culture
PresentationPurified immunoglobulin. Liquid in 0.02M phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Glial Fibrillary Acidic Protein using this Anti-Glial Fibrillary Acidic Protein Antibody validated for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern blot: 1:10,000 on rat brain

Optimal working dilutions must be determined by end user.
Biological Information
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG2a
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.
Gene Symbol
  • GFAP
  • FLJ45472
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
SIZE: 432 amino acids; 49880 Da
SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.
SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.
DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.
SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Packaging Information
Material Size100 µg
Global Trade Item Number
Katalógusszám GTIN
MAB5628 04053252727436