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MAB3402C3 Anti-GFAP Antibody, Cy3 Conjugate

Anti-GFAP Antibody, Cy3 Conjugate is an antibody against GFAP for use in IC, IH.

Anti-GFAP Antibody, Cy3 Conjugate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: GFAP UniProt Number: P14136
MAB3402C3
100 µL  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, R, Po, ChICC, IHCMCy3Monoclonal Antibody
Description
Catalogue NumberMAB3402C3
DescriptionAnti-GFAP Antibody, Cy3 Conjugate
Alternate Names
  • Glial fibrillary acidic protein
  • GFAP
Background InformationGlial fibrillary acidic protein is a class-III intermediate filament. GFAP is the main constituent of intermediate filaments in astrocytes and serves as a cell specific marker that distinguishes differentiated astrocytes from other glial cells during the development of the central nervous system.
References
Product Information
FormatCy3
HS Code3002 15 90
Control
  • Differentiated ReNcell VMs
PresentationPurified mouse monoclonal IgG1 conjugated to Cy3 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationAnti-GFAP Antibody, Cy3 Conjugate is an antibody against GFAP for use in IC, IH.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:100 dilution from a representative lot detected GFAP in adult mouse brain tissue.
Biological Information
ImmunogenPurified glial filament protein (Debus, E., 1983).
HostMouse
SpecificityThe antibody reacts with mouse GFAP. In tissue sections this
antibody stains astrocytes and Bergman glia cells (Debus, E., 1983).
IsotypeIgG1
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Pig
  • Chicken
Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human, Rat, Porcine, and Chicken based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
Gene Symbol
  • GFAP
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

SIZE: 432 amino acids; 49880 Da

SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.

SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.

DISEASE: Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.

SIMILARITY: Belongs to the intermediate filament family.
Molecular Weight50 kDa Observed (Using unconjugated antibody MAB3402)
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunocytochemistry in differentiated ReNcell VMs.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected GFAP in differentiated ReNcell VMs.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MAB3402C3 04053252421174

Documentation

Anti-GFAP Antibody, Cy3 Conjugate MSDS

Title

Safety Data Sheet (SDS) 

Anti-GFAP Antibody, Cy3 Conjugate Certificates of Analysis

TitleLot Number
Anti-GFAP, Cy3 Conjugate 2897242
Anti-GFAP, Cy3 Conjugate 2970687
Anti-GFAP, Cy3 Conjugate 3046765
Anti-GFAP, Cy3 Conjugate 2465295
Anti-GFAP, Cy3 Conjugate - 2370847 2370847
Anti-GFAP, Cy3 Conjugate - 2040912 2040912
Anti-GFAP, Cy3 Conjugate - 2181285 2181285
Anti-GFAP, Cy3 Conjugate - 2219391 2219391
Anti-GFAP, Cy3 Conjugate - 2290251 2290251
Anti-GFAP, Cy3 Conjugate - 2318826 2318826
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Product Families

Glial Cell Markers

Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
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Kategóriák

Life Science Research > Antibodies and Assays > Primary Antibodies