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AB5610-I-100UG Anti-GABA A Receptor alpha 6

Anti-GABA A Receptor alpha 6, Cat. No. AB5610-I, is a highly specific rabbit polyclonal antibody that targets Gamma-aminobutyric acid type A receptor alpha6 subunit and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-GABA A Receptor alpha 6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: GABRA6 UniProt Number: E1BE96
AB5610-I-100UG
100 μg  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, BWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB5610-I-100UG
DescriptionAnti-GABA A Receptor alpha 6
Alternate Names
  • Gamma-aminobutyric acid type A receptor alpha6 subunit
Background InformationGamma-aminobutyric acid type A receptor alpha 6 subunit (UniProt: E1BE96; also known as GABA A receptor alpha 6) is encoded by the GABRA6 gene (Gene ID: 539194) in bovine. GABA is the major inhibitory neurotransmitter in the central nervous system that inhibits the generation of the action potential of the neuron. It is involved in the pathogenesis of certain neurological and psychiatric disorders. GABA is produced from glutamic acid in a reaction catalyzed by glutamic acid decarboxylase. GABA interacts with the GABAA and GABAB receptors, which are widely distributed throughout the nervous system and in a variety of cell types. They differ in their pharmacological, electrophysiological, and biochemical properties. GABAA-receptor are pentameric membrane proteins that mediate an increase in membrane conductance with an equilibrium potential near the resting level of 70 mV. This conductance increase often is accompanied by a membrane hyperpolarization, which later results in a reduction in the probability of action potential initiation. The reduction in membrane resistance is accomplished by the GABA-dependent facilitation of chloride ion influx. Mos GABA A receptors contain one type of alpha and beta subunit, and a single gamma polypeptide in a ratio of 2:2:1. GABA A receptor alpha 6 subunit is synthesized with a signal peptide (aa 1-19), which is cleaved off in the mature form. It contains four transmembrane domains (aa 240-262, 274-293, 305-328, and 423-441).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-GABA A Receptor alpha 6, Cat. No. AB5610-I, is a highly specific rabbit polyclonal antibody that targets Gamma-aminobutyric acid type A receptor alpha6 subunit and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected GABA A Receptor alpha 6 in mouse cerebellum tissue sections.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 16 amino acids from the N-terminal region of bovine GABA A receptor alpha 6 subunit.
EpitopeN-terminus
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects GABA A receptor alpha 6 subunit. It targets an epitope with in 16 amino acids from the N-terminal region.
Species Reactivity
  • Rat
  • Bovine
Species Reactivity NoteBovine, Rat. Predicted to react with Mouse, Human based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • GABRA6
Purification MethodAffinity Purified
UniProt Number
Molecular Weight~51 kDa observed; 51.03 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in bovine brain membrane extract.

Western Blotting Analysis: 1 µg/mL of this antibody detected GABA A Receptor alpha 6 in bovine brain membrane extract.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
AB5610-I-100UG 04054839550836