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ABN438 Anti-ELFN1 Antibody

This Anti-ELFN1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of ELFN1.

Anti-ELFN1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: ELFN1, PPP1R28 UniProt Number: P0C7U0
ABN438
100 µg  
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Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN438
DescriptionAnti-ELFN1 Antibody
Alternate Names
  • Protein ELFN1
  • Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1
  • Protein phosphatase 1 regulatory subunit 28
Background InformationELFN1 is a postsynaptic protein that regulates circuit dynamics in the CNS by modulating the temporal dynamics of interneuron recruitment. ELFN1 is specifically expressed in excitatory synapses onto orens-lacunosum (OLM) interneurons and acts as a regulator of presynaptic release in directing of the pyramidal-OLM synapses. ELFN1 localizes to excitatory synapses on somatostatin containing OLM interneurons at the plasma membrane, and ELFN1 protein, expressed post-synaptically, can direct the elaboration of specific electrochemical properties of synapses between particular cell types in the hippocampus. ELFN1’s expression is found in distinct subsets of interneurons of the hippocampus and cortex, and also in discrete subsets of cells in the habenula, septum, globus pallidus, dorsal subiculum, amygdala and several other brain regions in the mouse. The protein is also expressed in diverse cell types, including local GABAergic interneurons as well as long-range projecting GABAergic and glutamatergic neurons.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ300
Applications
ApplicationThis Anti-ELFN1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of ELFN1.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected ELFN1 in human thalamus and rat cerebral cortex tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human ELFN1 near the N-terminal, extracellular domain.
EpitopeNear N-terminal, extracellular domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Monkey, Primate, Chimpanzee, Baboon, Hamster based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • ELFN1
  • PPP1R28
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~100 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in U2OS cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected ELFN1 in 10 µg of U2OS cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
ABN438 04053252996115

Documentation

Anti-ELFN1 Antibody Certificates of Analysis

TitleLot Number
Anti-ELFN1 - Q2454908 Q2454908