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MAB1476-I Anti-Chymotrypsin (Hu Pancreas) Antibody, clone CHYMO10-104.10

Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10, Cat. No. MAB1476-I, is a mouse monoclonal antibody that detects Trypsin and is tested for use in ELISA and Immunohistochemistry (Paraffin).

MAB1476-I
100 μg  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information
Description
Catalogue NumberMAB1476-I
DescriptionAnti-Chymotrypsin (Hu Pancreas) Antibody, clone CHYMO10-104.10
Background InformationChymotrypsin is a serine endopeptidase that is synthesized in the pancreatic acinar cells as chymotrypsinogen that is cleaved by trypsin to generate active chymotrypsin. Activation of chymotrypsinogen involves proteolytic cleavage at two sites. The resultant three chains are held together by five disulfide bonds. Chymotrypsin is reported to preferentially cleave peptide amide bonds where the carboxyl side of the amide bond (the P1 position) is a large hydrophobic amino acid (tyrosine, tryptophan, and phenylalanine). The aromatic ring in their sidechain that fits into a 'hydrophobic pocket' (the S1 position) of the enzyme. Two predominant forms of chymotrypsin have been described and are designated as chymotrypsin A and B. They display high degree of homology but have significantly different proteolytic characteristics. The active site residues in chymotrypsin are far apart in the primary sequence but are brought together in a crevice formed between the two protein domains.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody in buffer containing PBS, pH 7.4, containing no preservatives.
Quality LevelMQ100
Applications
ApplicationAnti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10, Cat. No. MAB1476-I, is a mouse monoclonal antibody that detects Trypsin and is tested for use in ELISA and Immunohistochemistry (Paraffin).
Key Applications
  • ELISA
  • Immunohistochemistry (Paraffin)
Application NotesELISA: (Dilution is assay dependent)

Immunohistochemistry: 1:1000.

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Biological Information
ImmunogenPurified human pancreatic chymotrypsin.
EpitopeUnknown
CloneCHYMO10-104.10
ConcentrationPlease refer to guidance on suggested starting dilutions and/or titers per application and sample type.
HostMouse
SpecificityClone CHYMO10-104.10 is a mouse monoclonal antibody that detects human Chymotrypsin.
IsotypeIgG1
Species Reactivity
  • Human
Species Reactivity NoteHuman
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • CTRL
  • CTRL1
  • chymotrypsin-like
  • MGC70821
  • EC 3.4.21
Purification MethodProtein G purified
UniProt Number
Molecular Weight28.0 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in convenient aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 L or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
MAB1476-I 04065265651394

Documentation

Anti-Chymotrypsin (Hu Pancreas) Antibody, clone CHYMO10-104.10 MSDS

Title

Safety Data Sheet (SDS) 

Anti-Chymotrypsin (Hu Pancreas) Antibody, clone CHYMO10-104.10 Certificates of Analysis

TitleLot Number
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 3919633 3919633
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4032736 4032736
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4047621 4047621
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4070801 4070801
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4080180 4080180
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4086383 4086383
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4094588 4094588
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4095806 4095806
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4128311 4128311
Anti-Chymotrypsin (Hu Pancreas), clone CHYMO10-104.10 - 4134657 4134657
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