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129874 Amifostine - CAS 20537-88-6 - Calbiochem

A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs.

Amifostine - CAS 20537-88-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate

129874
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
20537-88-6C₅H₁₅N₂O₃PS •3H₂O
Description
Overview

This product has been discontinued.



A cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.

Catalogue Number129874
Brand Family Calbiochem®
Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
References
ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
Yoon, Y.D., et al. 2005. In Vivo 19, 509.
Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
Product Information
CAS number20537-88-6
FormOff-white solid
Hill FormulaC₅H₁₅N₂O₃PS •3H₂O
Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
129874 0

Documentation

Amifostine - CAS 20537-88-6 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Amifostine - CAS 20537-88-6 - Calbiochem Certificates of Analysis

TitleLot Number
129874

References

Hivatkozások áttekintése
Dedieu, S., et al. 2010. BMC Medicine 8, 19.
Yoon, Y.D., et al. 2005. In Vivo 19, 509.
Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-May-2012 JSW
Synonyms2-(3-Aminopropyl)aminoethyl phosphorothioate, trihydrate, S-2-(3-Aminopropylamino)ethyl-O,O-dihydrogen phosphorothioate, trihydrate
DescriptionA cell-permeable aminothiophosphate pro-drug that offers selective protection in many normal, but not in tumor, tissues against the toxic side-effects of radiation and cytotoxic drugs. Its cytoprotective activities have been attributed to its free radical scavenging properties of its active thiol metabolite, WR-1065. The critical step in its activation is its interaction with alkaline phosphatase that is differentially distributed in normal and neoplastic cells. A strong inducer of hypoxia-inducible factor-α1 (HIF-α1) and p53. Shown to reduce PARP proteolysis and levels of active caspase-3 in irradiated mouse ovaries.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number20537-88-6
Chemical formulaC₅H₁₅N₂O₃PS •3H₂O
Structure formulaStructure formula
Purity≥99% by NMR
SolubilityH₂O
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesDedieu, S., et al. 2010. BMC Medicine 8, 19.
Yoon, Y.D., et al. 2005. In Vivo 19, 509.
Koukourakis, M.I., et al. 2004. Cancer Chemother. Pharmacol. 53, 1.
Blasiak, J., et al. 2002. Leukemia Res. 26, 1093.