500508 Sigma-AldrichATR Inhibitor III, ETP-46464 - CAS 1345675-02-6 - Calbiochem
Synonyms: ATM Inhibitor III, mTOR Inhibitor XIII, PI 3-K Inhibitor XIX, ETP46464, 2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATM and Rad3-Related Inhibitor III, Ataxia-Telangiectasia Mutated Inhibitor III, DNA-PK Inhibitor VI
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Áttekintés
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Kulcsspecifikációk táblázata
CAS # | Empirical Formula |
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1345675-02-6 | C₃₀H₂₂N₄O₂ |
Description | |
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Overview | A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC50 = 0.6, 14, 36, 170, and 545 nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500 nM) over ATM or DNA-PK activity (IC50 > 5 µM) in U2OS cells, while exhibiting much reduced or little potency toward a panel of 26 other kinases (>55% inhibition at 5 µM). Shown to synergize with UCN-01 (Cat. No. 539644) in replicative stress induction in S-phase replicating U2OS (1.5-, 61-, and 190-fold of control RS, respectively, with 1 µM ETP-46464, 50 nM UCN-01, or combined treatment). Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
Catalogue Number | 500508 |
Brand Family | Calbiochem® |
Synonyms | ATM Inhibitor III, mTOR Inhibitor XIII, PI 3-K Inhibitor XIX, ETP46464, 2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile, ATM and Rad3-Related Inhibitor III, Ataxia-Telangiectasia Mutated Inhibitor III, DNA-PK Inhibitor VI |
References | |
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References | Thanasoula, M., et al. 2012. EMBO J. 31, 3398. Toledo, L.I., et al. 2011. Nat Struct Mol Biol. 18, 721. |
Product Information | |
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CAS number | 1345675-02-6 |
Form | White powder |
Hill Formula | C₃₀H₂₂N₄O₂ |
Chemical formula | C₃₀H₂₂N₄O₂ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | ATR |
Primary Target IC<sub>50</sub> | 14 nM |
Purity | ≥99% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Materials Information |
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Safety Information according to GHS |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Katalógusszám | GTIN |
500508 | 0 |
Documentation
ATR Inhibitor III, ETP-46464 - CAS 1345675-02-6 - Calbiochem MSDS
Title |
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References
Hivatkozások áttekintése |
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Thanasoula, M., et al. 2012. EMBO J. 31, 3398. Toledo, L.I., et al. 2011. Nat Struct Mol Biol. 18, 721. |
Data Sheet | ||||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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