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155306 AMPA Agonist, CMPA - CAS 380607-77-2 - Calbiochem

The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.

AMPA Agonist, CMPA - CAS 380607-77-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator

155306
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
380607-77-2C₁₆H₂₈N₂O₄S₂

Products

KatalógusszámCsomagolás Menny./csomag
155306-5MG Üvegpalack 5 mg
Description
OverviewA bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
Catalogue Number155306
Brand Family Calbiochem®
SynonymsN,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
References
ReferencesTimm, D., et al. 2011. Mol. Pharm. 80, 267.
Product Information
CAS number380607-77-2
FormOff-white powder
Hill FormulaC₁₆H₂₈N₂O₄S₂
Chemical formulaC₁₆H₂₈N₂O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
155306-5MG 04055977207552

Documentation

AMPA Agonist, CMPA - CAS 380607-77-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

AMPA Agonist, CMPA - CAS 380607-77-2 - Calbiochem Certificates of Analysis

TitleLot Number
155306

References

Hivatkozások áttekintése
Timm, D., et al. 2011. Mol. Pharm. 80, 267.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-July-2012 JSW
SynonymsN,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
DescriptionA bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number380607-77-2
Chemical formulaC₁₆H₂₈N₂O₄S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, nearly colorless solution)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTimm, D., et al. 2011. Mol. Pharm. 80, 267.