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123855 AKR1C3 Inhibitor - CAS 1284180-11-5 - Calbiochem

123855
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
1284180-11-5C₁₄H₁₀F₃NO₂

Products

KatalógusszámCsomagolás Menny./csomag
123855-25MG Üvegpalack 25 mg
Description
OverviewA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
Catalogue Number123855
Brand Family Calbiochem®
Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
References
ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
Product Information
CAS number1284180-11-5
FormWhite powder
Hill FormulaC₁₄H₁₀F₃NO₂
Chemical formulaC₁₄H₁₀F₃NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥99% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
123855-25MG 04055977206302