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658430 AG 99

AG 99 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide

658430
  
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Áttekintés

Replacement Information
Description
Overview

This product has been discontinued.

Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 10 µM) and EGF-dependent cell proliferation. Inhibits EGFR phosphorylation and ERK1 and ERK2 activities.
Catalogue Number658430
Brand Family Calbiochem®
SynonymsTyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide
References
ReferencesPai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Product Information
CAS number118409-59-9
FormOff-white solid
Hill FormulaC₁₀H₈N₂O₃
Chemical formulaC₁₀H₈N₂O₃
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary Targetepidermal growth factor (EGF) receptor tyrosine kinase
Primary Target IC<sub>50</sub>10 µM
Secondary targetEGF-dependent cell proliferation, EGFR phosphorylation and ERK1 and ERK2 activities
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
658430 0

Documentation

AG 99 Certificates of Analysis

TitleLot Number
658430

References

Hivatkozások áttekintése
Pai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
SynonymsTyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide
DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 10 µM) and EGF-dependent cell proliferation.
FormOff-white solid
CAS number118409-59-9
Chemical formulaC₁₀H₈N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesPai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.