Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

658408 AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem

A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties.

AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4

Primary Target: apoptotic and antiproliferative properties
658408
  
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
581797-29-7C₁₈H₁₃F₃N₂O₃
Description
OverviewA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
Catalogue Number658408
Brand Family Calbiochem®
SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
References
ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
Product Information
CAS number581797-29-7
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₈H₁₃F₃N₂O₃
Chemical formulaC₁₈H₁₃F₃N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetapoptotic and antiproliferative properties
Primary Target IC<sub>50</sub>1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
658408 0

Documentation

AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

AG 490, m-CF₃ - CAS 581797-29-7 - Calbiochem Certificates of Analysis

TitleLot Number
658408

References

Hivatkozások áttekintése
Gu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.

Citations

Titulus
  • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-April-2011 RFH
    SynonymsNSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4
    DescriptionA cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC50 = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.
    FormYellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number581797-29-7
    Chemical formulaC₁₈H₁₃F₃N₂O₃
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (0.5 mg/ml) or Methanol
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.
    Toxicity Standard Handling
    ReferencesGu, L., et al. 2005. Bioorg. Med. Chem. 13, 4269.
    Citation
  • Yona Goldshmit, et al. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279, 16349-16355.
    		•