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152228 AEG3482

AEG3482 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 281D

152228
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
63735-71-7C₁₀H₈N₄O₂S₂
Description
Overview

This product has been discontinued.





A cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. Shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 µM).
Catalogue Number152228
Brand Family Calbiochem®
Synonyms6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 281D
References
ReferencesSalehi, A.H., et al. 2006. Chem. Biol. 13, 213.
Product Information
CAS number63735-71-7
FormLight yellow solid
Hill FormulaC₁₀H₈N₄O₂S₂
Chemical formulaC₁₀H₈N₄O₂S₂
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
152228 0

Documentation

AEG3482 Certificates of Analysis

TitleLot Number
152228

References

Hivatkozások áttekintése
Salehi, A.H., et al. 2006. Chem. Biol. 13, 213.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-February-2008 JSW
Synonyms6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide, 281D
DescriptionA cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. Shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 µM).
FormLight yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number63735-71-7
Chemical formulaC₁₀H₈N₄O₂S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (~28 mg/ml) or Ethanol (~1.4 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSalehi, A.H., et al. 2006. Chem. Biol. 13, 213.