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238900 4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM).

4-Cyano-3-methylisoquinoline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKA Inhibitor XI

Primary Target: PKA
238900
Purchase on Sigma-Aldrich

Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
161468-32-2C₁₁H₈N₂

Products

KatalógusszámCsomagolás Menny./csomag
238900-5MG Üvegpalack 5 mg
Description
OverviewA potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
Catalogue Number238900
Brand Family Calbiochem®
SynonymsPKA Inhibitor XI
References
ReferencesLu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.
Product Information
CAS number161468-32-2
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₁H₈N₂
Chemical formulaC₁₁H₈N₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA
Primary Target IC<sub>50</sub>30 nM against protein kinase A
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
238900-5MG 04055977216653

Documentation

4-Cyano-3-methylisoquinoline MSDS

Title

Safety Data Sheet (SDS) 

4-Cyano-3-methylisoquinoline Certificates of Analysis

TitleLot Number
238900

References

Hivatkozások áttekintése
Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Brochure

Title
Inhibitor Sourcebook 3rd Edition
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2011 RFH
SynonymsPKA Inhibitor XI
DescriptionA potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number161468-32-2
Chemical formulaC₁₁H₈N₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.