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585970 (±)-Thalidomide - CAS 50-35-1 - Calbiochem

Selective inhibitor of TNF-α biosynthesis.

(±)-Thalidomide - CAS 50-35-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Primary Target: TNF-α biosynthesis
585970
  
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
50-35-1C₁₃H₁₀N₂O₄
Description
OverviewSelective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
Catalogue Number585970
Brand Family Calbiochem®
Synonyms(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
References
ReferencesGershon, D. 1995. Nat. Med. 1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
Product Information
CAS number50-35-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₃H₁₀N₂O₄
Chemical formulaC₁₃H₁₀N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTNF-α biosynthesis
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSTI4375000
Safety Information
R PhraseR: 21-25-46-61-62

Harmful in contact with skin.
Toxic if swallowed.
May cause heritable genetic damage.
May cause harm to the unborn child.
Possible risk of impaired fertility.
S PhraseS: 36/37/39-45-22-26

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
585970 0

Documentation

(±)-Thalidomide - CAS 50-35-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

(±)-Thalidomide - CAS 50-35-1 - Calbiochem Certificates of Analysis

TitleLot Number
585970

References

Hivatkozások áttekintése
Gershon, D. 1995. Nat. Med. 1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-February-2014 JSW
Synonyms(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
DescriptionSelective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
FormWhite solid
CAS number50-35-1
RTECSTI4375000
Chemical formulaC₁₃H₁₀N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic & Carcinogenic / Teratogenic
Merck USA index14, 9255
ReferencesGershon, D. 1995. Nat. Med. 1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.