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376820 β-Hexosaminidase Inhibitor - CAS 281224-40-6 - Calbiochem

376820
  
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Áttekintés

Kulcsspecifikációk táblázata

CAS #Empirical Formula
281224-40-6C₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Description
Overview

This product has been discontinued.



A cell-permeable bisnaphthalimide compound that acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 and 3.1 µM for hHex A and hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN. Shown to function as a pharmacological chaperone and effectively enhance the transport of mutant Hex alpha subunit from the ER to lysosome in cells derived from ISD and ATSD patients.

Catalogue Number376820
Brand Family Calbiochem®
SynonymsM-31850
References
ReferencesTropak, M.B., et al. 2007. Chem. Biol. 14, 153.
Product Information
CAS number281224-40-6
FormWhite solid
Hill FormulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Chemical formulaC₂₈H₂₁N₃O₄ • 1/2(CH₃OH)
Structure formula ImageStructure formula Image
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at 20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Katalógusszám GTIN
376820 0